Research Papers/Books

Original papers

  1. Tahara Y, Makino S, Suiko T, Nagamori Y, Iwai T, Aono M, Shibata S, Association between Irregular Meal Timing and the Mental Health of Japanese Workers, Nutrients, 13:2775, 2021

  2. Tahara Y, Shinto T, Inoue K, Roshanmehr F, Ito A, Michie M, and Shibata S, Changes in sleep phase and body weight of mobile health App users during COVID-19 mild lockdown in Japan, International Journal of Obesity, 2021, online.

  3. Aoyama S, Kim HK, Hirooka R, Tanaka M, Shimoda T, Chijiki H, Kojima S, Sasaki K, Takahashi K, Makino S, Takizawa M, Takahashi M, Tahara Y, Shimba S, Shinohara K, Shibata S, Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock, Cell Reports, 2021, 36:109336.

  4. Miyazaki S, Tahara Y, Colwell CS, Block GD, Nakamura W, Nakamura TJ, Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus, Neurobiology of Sleep and Circadian Rhythms, 2021, 11, 100070.

  5. Fujita H, Yamagishi K, Zhou W, Tahara Y, Huang SY, Hashimoto M, Fujie T, Design and fabrication of a flexible glucose sensing platform toward rapid battery-free detection of hyperglycaemia, Journal of Materials Chemistry C, 2021, DOI: 10.1039/d1tc00667c.

  6. Haraguchi A, Nishimura Y, Fukuzawa M, Kikuchi Y, Tahara Y, Shibata S, Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning, Chronobiology Int., 2020, Dec 20;1-17.

  7. Wang HB, Tahara Y, Luk SHC, Kim YS, Hitchcock ON, Kaswan MZA, Kim YI, Block GD, Ghiani CA, Loh DH, Colwell CS, Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder, Neurobiology of Disease, 2020, 145: 105064.

  8. Motohashi H*, Tahara Y*, Whittaker DS, Wang HB, Yamaji T, Wakui H, Haraguchi A, Yamazaki M, Miyakawa H, Hama K, Sasaki H, Sakai T, Hirooka R, Takahashi K, Takizawa M, Makino S, Aoyama S, Colwell CS, and Shibata S, The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy, Kidney International, 2020, 97: 728-740 (*Equal contribution).

  9. Aoyama S, Kojima S, Sasaki K, Shimoda T, Takahashi K, Hirooka R, Tahara Y, Shibata S, Effects of day-time feeding on murine skeletal muscle growth and synthesis. Journal of Nutrition & Intermediary Metabolism, 2019, 17: 100099.

  10. Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T. The effect of night shift work on the expression of clock genes in beard hair follicle cells. Sleep Med. 2019, pii: S1389-9457(18)30593-30598. ⇒Pubmed

  11. Morinaga K, Sasaki H, Park S, Hokugo A, Okawa H, Tahara Y, Colwell CS, Nishimura I.Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism. Biomaterials.2019, 192:62-74. ⇒Pubmed

  12. Kuljis D, Kudo T, Tahara Y, Ghiani CA, Colwell CS, Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease. J Neurosci Res. 2018, 96:1862-1875. ⇒Pubmed

  13. Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS, Circadian-based treatment strategy effective in the BACHD mouse model of Huntington’s disease, Journal of Biological rhythms, 2018, 33:535-554. ⇒Pubmed

  14. Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, and Shibata S, Chronotype and social jetlag influence human circadian clock gene expression, Scientific Reports, 2018, 8:10152. ⇒Pubmed

  15. Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function. Scientific Reports, 2018, 8:9072. ⇒Pubmed

  16. Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, Haraguchi A, Ikeda Y, Fukuda S, Shibata S. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainme5t in Mouse Peripheral Tissue. Scientific Reports, 2018, 8:1395. ⇒Pubmed

  17. Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S. Night eating model shows time-specific depression-like behavior in the forced swimming test. Scientific Reports, 2018, 8:1081. ⇒Pubmed

  18. Hassan N, McCarville K, Morinaga K, Mengatto CM, Langfelder P, Hokugo A, Tahara Y, Colwell CS, Nishimura I, Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PLoS ONE, 2017, 12:e0183359.⇒PubMed

  19.  Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S, Potent Synchronization of Peripheral Circadian Clocks by Glucocorticoid Injections in PER2::LUC-Clock/Clock mice. Chronobiol Int., 2017, 13:1-16. ⇒PubMed

  20. Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S, Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice, Nutrition Research, 2017, 43:16-24.⇒Nutrition Research

  21. Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S, Potent Effects of Flavonoid Nobiletin on Ampliturde, Period, and Phase of the Circadian Clock Rhythm in PER2::LUC Mouse Embryonic Fibroblasts. PLoS One. 2017, 12:e0170904.⇒PubMed

  22. Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S, Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation, npj Aging and Mechanisms and Disease, 2017, 3:16030.⇒npj Aging HP⇒Nature Asia

  23. Takahashi M, Haraguchi A, Tahara Y, Aoki N, Fukuzawa M, Tanisawa K, Ito T, Nakaoka T, Higuchi M, Shibata S, Positive association between physical activity and PER3 expression in older adults. Scientific Reports, 2017, 7:39771.⇒PubMed

  24. Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S, Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice. Scientific Reports, 2016, 6:27607.⇒PubMed

  25. Tahara Y, Yokota A, Shiraishi T, Yamada S, Haraguchi A, Shinozaki A, Shibata S, In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress, Journal of Circadian Rhythms, 2016, 14:1-7. ⇒JCR HP

  26. Li H, Ohta H, Tahara Y, Nakamura S, Taguchi K, Nakagawa M, Oishi Y, Goto Y, Wada K, Saga M, Inagaki M, Otagiri M, Yokota H, Shibata S, Sakai H, Okamura K, Yaegashi N, Artificial oxygen carriers rescue placental  hypoxia and improve fetal development in the rat pre-eclampsiamodel.  Scientific Reports, 2015, 5:15271.⇒PubMedプレスリリース

  27. Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S., Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Scientific Reports, 2015, 5:14424.⇒PubMed

  28. Hamaguchi Y*, Tahara Y*, Kuroda H, Haraguchi A, Shibata S. Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions. Scientific Reports, 2015, 5:14207. (*equal contribution)⇒PubMed

  29. Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Recovered by Scheduled Feeding or Exercise. J Biological Rhythms, 2015, 30:533-542. ⇒PubMed

  30. Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PLoS ONE, 2015, 10:e0132472. ⇒PubMed

  31. Tahara Y, Shiraishi T, Kikuchi Y, Haraguchi A, Kuriki D, Sasaki H, Motohashi H, Sakai T & Shibata S. Entrainment of the mouse circadian clock by sub-acute physical and psychological stress. Scientific Reports, 2015, 5:11417. ⇒Journal注目の論文

  32. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala. Sleep Medicine, 2015, 16:1352-1359. ⇒PubMed

  33. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice. Neuroscience Research, 2015, 99:16-21. ⇒PubMed

  34. Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S, Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods. Chronobiology International, 2015, 32:195-210. ⇒PubMed

  35. Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y,Shibata S. Effects of caffeine on circadian phase, amplitude, and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice. British Journal of Pharmacology, 2014, 171:5858-5869. ⇒PubMed

  36. Aoki N, Yoshida D, Ishikawa R, Ando M, Nakamura K, Tahara Y, and Shibata S, A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice. Nutr Res, 2014, 34:613-622. ⇒PubMed

  37. Moriya S, Tahara Y, Sasaki H, Hamaguchi Y, Kuriki D, Ishikawa R, Ishigooka J, Shibata S, Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus. J Pharmacol Sci, 2014, 125:329-332. ⇒PubMed

  38. Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, and Shibata S, Controlling access time to a high fat diet during the inactive period protects against obesity in mice, Chronobiology International, 2014, 31:935-944. ⇒PubMed

  39. Ohnishi N*, Tahara Y*, Kuriki D, Haraguchi A, and Shibata S, Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse, PLoS ONE, 2014, 9:e100272, (*These authors equally contributed this work.) ⇒PubMed

  40. Nakamura Y*, Ishimaru K*, Tahara Y*, Shibata S, Nakao A, Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice, J Immunological Research, 2014, 2014:ID474217. (*These authors equally contributed this work.) ⇒PubMed

  41. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A, Circadian Regulation of Allergic Reaction by the Mast Cell Clock. J Allergy Clin Immunol, 2014, 133:568-575. ⇒PubMed

  42. Kudo T, Loh DH, Tahara Y, Truong D, Hernández-Echeagaray E, Colwell CS, Circadian dysfunction in response to the in vivo treatment with the mitochondrial toxin 3-nitropropionic acid. ASN Neuro, 2014, 6:e00133. ⇒PubMed

  43. KudoT, Tahara Y, Gamble KL, McMahon DG, Block GD, Colwell CS, Vasoactive intestinal peptide produces long lasting changes in neural activity in the suprachiasmatic nucleus. J of Neurophysiol, 2013, 110: 1097-1106. ⇒PubMed

  44. Kuroda H*, Tahara Y*, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S, Meal frequency patterns determine the phase of mouse peripheral circadian clocks. Sci Rep, 2012, 2: 711. (*These authors equally contributed this work.) ⇒PubMed

  45. Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S, Biological clock dysfunction exacerbates contact hypersensitivity in mice. Br J Dermatol, 2012, 168; 39-46. ⇒PubMed

  46. Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S, Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. J Circadian Rhythms, 2012, 10: 4. ⇒PubMed

  47. Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S, In Vivo Monitoring of Peripheral Circadian Clocks in the Mouse. Current Biology, 2012, 22: 1029-1034. ⇒PubMed

  48. Kubo Y, Tahara Y, Hirao A, Shibata S, 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity. J Pharmacol Exp Ther, 2012, 340: 698-705. ⇒PubMed

  49. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I, Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem, 2011, 54: 6295-6304. ⇒PubMed

  50. Tahara Y, Otsuka M, Fuse Y,Hirao A, and Shibata S, Restricted feeding elicits insulin-dependent regulation of Per2 and Rev-erba gene expression as an early step in entrainment of the liver clock, J Biol Rhythms, 2011, 26: 230-240. ⇒PubMed

  51. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A, The circadian clock gene Period2 regulates a time of day-dependent variation in cutanenous anaphylactic reaction. J Allergy Clin Immunol, 2011, 127: 1038-1045. ⇒PubMed

  52. Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, Shibata S. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::luc knock-in mice under two meals per day feeding. Am J Physiol Gastrointest Liver Physiol, 2010, 299: G1045-1053. ⇒PubMed

  53. Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S, Dorsomedial hypothalamus is not necessary for the feeding-induced entrainment of liver circadian rhythm in Per2::luc knock-in mouse. J Biol Rhythms, 2010, 25: 9-18. ⇒PubMed

  54. Hirao A, Tahara Y, Kimura I, Shibata S, A balanced diet is necessary for proper entrainment signals of the mouse liver clock. PLoS One, 2009, 4, e6909. ⇒PubMed

 

Reviews/Books/Chapters

  1. 駒田陽子、田原優 翻訳「おしゃべりなネコに学ぶ からだの中の大切な時計」by マヌエル・シュピッツァン、2021年10月19日

  2. ​田原 優、「体内時計と感染症、免疫」『特集 感染症予防に効果的な生活習慣』体育の科学、杏林書院、2021年5月

  3. 田原 優、医学のあゆみ TOPICS「慢性腎臓病により体内時計が乱れる」、2020年9月

  4. 田原 優、「精神・神経と時間栄養学」、アグリバイオ、北隆館、2020年8月

  5. 田原 優、「2章 時間栄養学の測定法・方法論(マウス・ヒト)」、「11章 糖尿病と時間栄養学」、『時間栄養学』、化学同人、2020年7月

  6. 田原 優、「体内時計から考える健康科学」、食と医療、講談社、2020年1月

  7. 田原 優、「脳と時間栄養」アンチ・エイジング医学、日本抗加齢医学会、2019年12月

  8. 田原 優、「食事のタイミングと代謝・腸内環境」、体育の科学、杏林書院、2019年11月

  9. 田原 優、「エネルギー代謝・肥満と時間栄養学研究」、食品と開発、2019年10月

  10. 田原 優、『体を整えるすごい時間割』、大和書房、2019. ⇒Amazon  ⇒大和書房

  11. 田原 優、「体内時計と時間栄養」、『特集『時間』を軸に考えた糖尿病治療の新展開』、月刊糖尿病、医学出版、2018年7月 ⇒月刊糖尿病

  12. 田原 優、「時間栄養学的な観点からの疾病予防」、『特集・実臨床に向けた時間医薬研究の新動向』、医療ジャーナル、2018年6月、123-128 ⇒医療ジャーナル

  13. 田原 優、柴田 重信、『Q&Aですらすらわかる 体内時計健康法』、杏林書院、2017. ⇒杏林書院

  14. 田原 優、柴田 重信、「体内時計、時間栄養学」、『食品機能成分の吸収・代謝・作用機序』、シーエムシー出版、2018、30-37. ⇒シーエムシー出版

  15. Tahara Y and Shibata S, Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition. Free Radic Biol Med. 2017 ⇒Pub Med

  16. Tahara Y and Shibata S, Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer. Hepatology, 2016, 65:1061-1064. ⇒Pub Med

  17. 柴田 重信、田原 優、「日内変動・生物リズム」、マウス表現型解析スタンダード、実験医学、羊土社、2016、289-294.

  18. Tahara Y, Aoyama S, Shibata S, The mammalian circadian clock and its entrainment by stress and exercise. J Physiological Science, 2017, 76:1-10.  ⇒Pub Med

  19. Tahara Y & Shibata S, Circadian rhythms of liver physiology and disease: experimental and clinical evidence, Nature Reviews Gastroenterology and Hepatology, 2016, 13:217-226. ⇒Nature Reviews

  20. Yu Tahara, Hiroyuki Sasaki, Shigenobu Shibata, Chrono-nutrition and Chrono-exercise in Mice, アショフホンマ財団 『Circadian Clocks』, 2015, p53-59.

  21. 田原 優「連載〜概日時計研究を健康に活かす〜」、全7回、体育の科学、杏林書院、2015、11月号〜 ⇒杏林書院

  22. 柴田 重信、田原 優「時間薬理・栄養・運動学の研究最前線」、実験医学11月号、2015、p3008-3011. ⇒羊土社

  23. Shibata S, Tahara Y, Circadian Rhythm & Exercise, J Phys Fitness Sports Med., Review, 2014, 3:65-72. ⇒J Phys Fitness Sports Med

  24. Tahara Y, Shibata S, Chrono-biology, chrono-pharmacology, and chrono-nutrition, J pharm Sci., Review, 2014, 124:320-335. ⇒PubMed

  25. Tahara Y, Shibata S, Chronobiology and Nutrition. Neuroscience, Review, 2013, 253: 78-88. ⇒PubMed

  26. Tahara Y, Shibata S, Nutrition and diet as potent regulators of the liver clock. Circadian Medicine, Wiley, in press ⇒Wiley

  27. Tahara Y, Shibata S, Circadian rhythm and food/nutrition. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, Springer, 2014, 237-260. ⇒Springer

  28. 田原 優、柴田 重信、「時間栄養と心の健康〜食品との関わりも含めて」『FOOD STYLE 21』、食品化学新聞社、2013年8月、p42-44. ⇒食品化学新聞社

  29. 田原 優、柴田 重信、「時間栄養学」『食品機能性成分の吸収・代謝機構』、シーエムシー出版、2013年5月、p28-36. ⇒シーエムシー出版

  30. 田原 優、柴田 重信、「日内リズムを作る身体のしくみ」『子どもと発育発達』、日本発育発達学会、杏林書院、2011, 8: p259-263. ⇒杏林書院

  31. 田原 優、 柴田 重信、「子供の体内時計と遺伝」、『乳幼児医学・心理学研究』、日本乳幼児医学・心理学会、2010, 19, 89-96.

  32. Shibata S, Tahara Y, Hirao A, The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs, Advanced Drug Delivery Reviews, 2010, 62, 918-927. ⇒PubMed

  33. 田原 優、柴田 重信、「行動薬理研究における実験技術~概日リズム評価法~」、『実践行動薬理学』、日本薬理学会、金芳堂、第Ⅰ編、4章、p27-p34.     ⇒日本薬理学会

  34. Shibata S, Hirao A, Tahara Y, Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm, Sleep & Biological Rhythms, 2010, 8, 18-27. ⇒Wiley