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Research Papers/Books

Original papers

  1. Kuwahara M, Tahara Y, Nitta L, Furutani A, Mochida S, Makino N, Nozawa Y, Shibata S, Association of breakfast styles such as Japanese, Western and Cereals on sleeping habits, eating habits and lifestyle in preschooler and elementary school children, Frontiers in Nutrition, 2023, in press.

  2. Nitta L, Tahara Y, Shinto T, Makino S, Kuwahara M, Tada A, Abe N, Michie M, Shibata S, Association of Eating Pattern, Chronotype, and Social Jetlag: A Cross-Sectional Study Using Data Accumulated in a Japanese Food-Logging Mobile Health Application, Nutrients, 2023, 15:2165.

  3. Shiga K, Haraguchi A, Sasaki H, Tahara Y, Orihara K, Shibata S, Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract, Bioscience of Microbiota, Food and Health, in press.

  4. Kuwahara M, Tahara Y, Suiko T, Nagamori Y, Shibata S, Effects of differences of breakfast styles, such as Japanese and 
    Western breakfasts, on eating and dietary habits,Nutrients, 2022, 14: 5143.

  5. Shinto T, Tahara Y, Watabe A, Makino N, Tomonaga M, Kimura H, Nozawa Y, Kobayashi K, Takahashi M, Shibata S, Interaction effects of sex on the sleep loss and social jetlag-related negative mood in Japanese children and adolescents : A cross-sectional study,SLEEP Advances, 2022, 3: zpac035.

  6. Imamura M, Tahara Y, Suiko T, Nagamori Y, Shibata S, Association between blood pressure and circadian timing of physical activity of Japanese workers,Frontiers in Physiology, 13:992945.

  7. Roshanmehr F, Tahara Y, Makino S, Tada A, Abe N, Michie M, and Shibata S, Association of Japanese Breakfast Intake with Macro- and Micronutrients and Morning Chronotype,Nutrients, 2022, 14: 3496.

  8. Roshanmehr F, Hayashi K, Tahara Y, Suiko T, Nagamori Y, Iwai T, and Shibata S, Association between Breakfast Meal Categories and Timing of Physical Activity of Japanese Workers,Foods, 2022, 11:2609.

  9. Shinto T, Tahara Y, Makino S, Nitta L, Kuwahara M, Tada A, Abe N, Michie M, Shibata S, Relationship between protein intake in each meal and physical activity level: Cross-sectional Study,_cc781905-5cde-3194- bb3b-136bad5cf58d_JMIR Public Health and Surveillance, 2022, 8: e35898.

  10. Haraguchi A, Saito K, Tahara Y, Shigenobu S, Polygalae Radix shortens the circadian period through the activation of the CaMKII pathway, Pharmaceutical biology, 2022, 60: 689-698.

  11. Imamura M, Sasaki H, Shinto T, Tahara Y, Makino S, Kuwahara M, Tada A, Abe N, Michie M, Shibata S, Association between Na, K, and lipid intake in each meal and blood pressure,Frontiers in Nutrition, 2022, 9: 853118.

  12. Tahara Y*, Makino S, Suiko T, Nagamori Y, Iwai T, Aono M, Shibata S*, Association between Irregular Meal Timing and the Mental Health of Japanese Workers,Nutrients, 13:2775, 2021 (*Corresponding author)

  13. Tahara Y, Shinto T, Inoue K, Roshanmehr F, Ito A, Michie M, and Shibata S, Changes in sleep phase and body weight of mobile health App users during COVID-19 mild lockdown in Japan,International Journal of Obesity, 2021, 45:2277-2280.

  14. Aoyama S, Kim HK, Hirooka R, Tanaka M, Shimoda T, Chijiki H, Kojima S, Sasaki K, Takahashi K, Makino S, Takizawa M, Takahashi M, Tahara Y, Shimba S, Shinohara K, Shibata S, Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock,Cell Reports, 2021, 36:109336.

  15. Miyazaki S, Tahara Y, Colwell CS, Block GD, Nakamura W, Nakamura TJ, Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus,Neurobiology of Sleep and Circadian Rhythms, 2021, 11, 100070.

  16. Fujita H, Yamagishi K, Zhou W, Tahara Y, Huang SY, Hashimoto M, Fujie T, Design and fabrication of a flexible glucose sensing platform toward rapid battery-free detection of hyperglycaemia,Journal of Materials Chemistry C, 2021, DOI: 10.1039/d1tc00667c.

  17. Haraguchi A, Nishimura Y, Fukuzawa M, Kikuchi Y, Tahara Y, Shibata S, Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning,Chronobiology Int., 2021, 38: 426-442.

  18. Wang HB, Tahara Y, Luk SHC, Kim YS, Hitchcock ON, Kaswan MZA, Kim YI, Block GD, Ghiani CA, Loh DH, Colwell CS, Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder,Neurobiology of Disease, 2020, 145: 105064.

  19. Motohashi H*, Tahara Y*, Whittaker DS, Wang HB, Yamaji T, Wakui H, Haraguchi A, Yamazaki M, Miyakawa H, Hama K, Sasaki H, Sakai T, Hirooka R, Takahashi K, Takizawa M, Makino S, Aoyama S, Colwell CS, and Shibata S, The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy,Kidney International,2020, 97: 728-740 (*Equal contribution).

  20. Aoyama S, Kojima S, Sasaki K, Shimoda T, Takahashi K, Hirooka R, Tahara Y, Shibata S, Effects of day-time feeding on murine skeletal muscle growth and synthesis.Journal of Nutrition & Intermediary Metabolism, 2019, 17: 100099.

  21. Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T. The effect of night shift work on the expression of clock genes in beard hair follicle cells .Sleep Med.2019, pii: S1389-9457(18)30593-30598.⇒Pubmed

  22. Morinaga K, Sasaki H, Park S, Hokugo A, Okawa H, Tahara Y, Colwell CS, Nishimura I.Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism.Biomaterials.2019, 192:62-74. ⇒Pubmed

  23. Kuljis D, Kudo T, Tahara Y, Ghiani CA, Colwell CS, Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease.J Neurosci Res2018, 96:1862-1875. ⇒Pubmed

  24. Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS, Circadian-based treatment strategy effective in the BACHD mouse model of Huntington's disease,Journal of Biological rhythms, 2018, 33:535-554. ⇒Pubmed

  25. Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, and Shibata S, Chronotype and social jetlag influence human circadian clock gene expression,Scientific Reports, 2018, 8:10152. ⇒Pubmed

  26. Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor -1 and its scaffolding function.Scientific Reports, 2018, 8:9072. ⇒Pubmed

  27. Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, Haraguchi A, Ikeda Y, Fukuda S, Shibata S. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainme5t in Mouse Peripheral Tissue.Scientific Reports, 2018, 8:1395. ⇒Pubmed

  28. Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S. Night eating model shows time-specific depression-like behavior in the forced swimming test.Scientific Reports, 2018, 8:1081. ⇒Pubmed

  29. Hassan N, McCarville K, Morinaga K, Mengatto CM, Langfelder P, Hokugo A, Tahara Y, Colwell CS, Nishimura I, Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells.PLoS ONE, 2017, 12:e0183359.⇒PubMed

  30.  Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S, Potent Synchronization of Peripheral Circadian Clocks by Glucocorticoid Injections in PER2::LUC-Clock/Clock mice.Chronobiol Int., 2017, 13:1-16. ⇒PubMed

  31. Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S, Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice,Nutrition Research, 2017, 43:16-24.⇒Nutrition Research

  32. Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S, Potent Effects of Flavonoid Nobiletin on Ampliturde, Period, and Phase of the Circadian Clock Rhythm in PER2::LUC Mouse Embryonic Fibroblasts.PLoS One2017, 12:e0170904.⇒PubMed

  33. Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S, Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation,npj Aging and Mechanisms and Disease,2017, 3:16030.⇒npj Aging HP, ⇒Nature Asia

  34. Takahashi M, Haraguchi A, Tahara Y, Aoki N, Fukuzawa M, Tanisawa K, Ito T, Nakaoka T, Higuchi M, Shibata S, Positive association between physical activity and PER3 expression in older adults. Scientific Reports, 2017, 7:39771 .⇒PubMed

  35. Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S, Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.Scientific Reports, 2016, 6:27607.⇒PubMed

  36. Tahara Y, Yokota A, Shiraishi T, Yamada S, Haraguchi A, Shinozaki A, Shibata S, In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress,Journal of Circadian Rhythms, 2016, 14:1-7. ⇒JCR HP

  37. Li H, Ohta H, Tahara Y, Nakamura S, Taguchi K, Nakagawa M, Oishi Y, Goto Y, Wada K, Saga M, Inagaki M, Otagiri M, Yokota H, Shibata S, Sakai H, Okamura K, Yaegashi N , Artificial oxygen carriers rescue placental  hypoxia and improve fetal development in the rat pre-eclampsiamodel.Scientific Reports,2015, 5:15271.⇒PubMed,press release

  38. Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S., Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model.Scientific Reports, 2015, 5:14424.⇒PubMed

  39. Hamaguchi Y*, Tahara Y*, Kuroda H, Haraguchi A, Shibata S. Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions.Scientific Reports,2015, 5:14207. (*equal contribution)⇒PubMed

  40. Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Recovered by Scheduled Feeding or Exercise.J Biological Rhythms, 2015, 30:533-542. ⇒PubMed

  41. Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.PLoS ONE, 2015, 10:e0132472. ⇒PubMed

  42. Tahara Y, Shiraishi T, Kikuchi Y, Haraguchi A, Kuriki D, Sasaki H, Motohashi H, Sakai T & Shibata S. Entrainment of the mouse circadian clock by sub-acute physical and psychological stress.Scientific Reports, 2015, 5:11417. ⇒Journal, Featured paper

  43. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala.Sleep Medicine,2015, 16:1352-1359. ⇒PubMed

  44. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice.Neuroscience Research,2015, 99:16-21. ⇒PubMed

  45. Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S, Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods.Chronobiology International, 2015, 32:195-210. ⇒PubMed

  46. Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y, Shibata S. Effects of caffeine on circadian phase, amplitude, and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.British Journal of Pharmacology,2014, 171:5858-5869. ⇒PubMed

  47. Aoki N, Yoshida D, Ishikawa R, Ando M, Nakamura K, Tahara Y, and Shibata S, A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice.Nutr Res,2014, 34:613-622. ⇒PubMed

  48. Moriya S, Tahara Y, Sasaki H, Hamaguchi Y, Kuriki D, Ishikawa R, Ishigooka J, Shibata S, Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus.J Pharmacol Sci, 2014, 125:329-332. ⇒PubMed

  49. Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, and Shibata S, Controlling access time to a high fat diet during the inactive period protects against obesity in mice,Chronobiology International, 2014, 31:935-944. ⇒PubMed

  50. Ohnishi N*, Tahara Y*, Kuriki D, Haraguchi A, and Shibata S, Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse,PLoS ONE, 2014, 9:e100272, (*These authors equally contributed this work.) ⇒PubMed

  51. Nakamura Y*, Ishimaru K*, Tahara Y*, Shibata S, Nakao A, Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice,J Immunological Research,2014, 2014: ID474217. (*These authors equally contributed this work.) ⇒PubMed

  52. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A, Circadian Regulation of Allergic Reaction by the Mast Cell Clock.J Allergy Clin Immunol, 2014, 133:568-575. ⇒PubMed

  53. Kudo T, Loh DH, Tahara Y, Truong D, Hernández-Echeagaray E, Colwell CS, Circadian dysfunction in response to the in vivo treatment with the mitochondrial toxin 3-nitropropionic acid.ASN Neuro,2014, 6:e00133. ⇒PubMed

  54. KudoT, Tahara Y, Gamble KL, McMahon DG, Block GD, Colwell CS, Vasoactive intestinal peptide produces long lasting changes in neural activity in the suprachiasmatic nucleus.J of Neurophysiol,2013, 110: 1097-1106. ⇒PubMed

  55. Kuroda H*, Tahara Y*, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S, Meal frequency patterns determine the phase of mouse peripheral circadian clocks.Sci Rep, 2012, 2: 711. (*These authors equally contributed this work.) ⇒PubMed

  56. Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S, Biological clock dysfunction exacerbates contact hypersensitivity in mice.Br J Dermatol,2012, 168; 39-46. ⇒PubMed

  57. Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S, Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.J Circadian Rhythms, 2012, 10: 4. ⇒PubMed

  58. Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T , Shibata S, In Vivo Monitoring of Peripheral Circadian Clocks in the Mouse.Current Biology,2012, 22: 1029-1034. ⇒PubMed

  59. Kubo Y, Tahara Y, Hirao A, Shibata S, 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity.J Pharmacol Exp Ther, 2012, 340: 698-705. ⇒PubMed

  60. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I, Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.J Med Chem, 2011, 54: 6295-6304. ⇒PubMed

  61. Tahara Y, Otsuka M, Fuse Y, Hirao A, and Shibata S, Restricted feeding elicits insulin-dependent regulation of Per2 and Rev-erba gene expression as an early step in entrainment of the liver clock,J Biol Rhythms,2011, 26: 230-240. ⇒PubMed

  62. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A, The circadian clock gene Period2 regulates a time of day-dependent variation in Cutanenous anaphylactic reaction.Allergy Clin Immunol,2011, 127: 1038-1045. ⇒PubMed

  63. Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, Shibata S. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::luc knock-in mice under two meals per day feeding.Am J Physiol Gastrointest Liver Physiol,2010, 299: G1045-1053. ⇒PubMed

  64. Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S, Dorsomedial hypothalamus is not necessary for the feeding-induced entrainment of liver circadian rhythm in Per2::luc knock-in mouse.J Biol Rhythms, 2010, 25: 9-18. ⇒PubMed

  65. Hirao A, Tahara Y, Kimura I, Shibata S, A balanced diet is necessary for proper entrainment signals of the mouse liver clock.PLoS One, 2009, 4, e6909. ⇒PubMed

 

Reviews/Books/Chapters​

  1. Tahara Y, Qian J, Oike H, Escobar C, Editorial: The Present and Future of Chrono-nutrition Studies, Frontiers in Nutrition, 2023, 10: 2023.

  2. Takahashi M, Tahara Y, Timing of Food/Nutrient Intake and Its Health Benefits, J Nutr Sci Vitaminol, 2022, 68:S2-S4.

  3. Tahara Y and Shibata S, Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition. Free Radic Biol Med. 2017, 119:129-138.

  4. Tahara Y and Shibata S, Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer. Hepatology, 2016, 65:1061-1064.

  5. Tahara Y, Aoyama S, Shibata S, The mammalian circadian clock and its entrainment by stress and exercise. J Physiological Science, 2017, 76:1-10. 

  6. Tahara Y & Shibata S, Circadian rhythms of liver physiology and disease: experimental and clinical evidence, Nature Reviews Gastroenterology and Hepatology, 2016, 13:217-226.

  7. Shibata S, Tahara Y, Circadian Rhythm & Exercise, J Phys Fitness Sports Med., Review, 2014, 3:65-72.

  8. Tahara Y, Shibata S, Chrono-biology, chrono-pharmacology, and chrono-nutrition, J Pharm Sci., Review, 2014, 124:320-335.

  9. Tahara Y, Shibata S, Chronobiology and Nutrition. Neuroscience, Review, 2013, 253: 78-88.

  10. Tahara Y, Shibata S, Nutrition and diet as potent regulators of the liver clock. Circadian rhythms: Health and Disease, Wiley, chapter 7, 2015.

  11. Yu Tahara, Hiroyuki Sasaki, Shigenobu Shibata, Chrono-nutrition and Chrono-exercise in Mice, アショフホンマ財団 『Circadian Clocks』, 2015, p53-59.

  12. Tahara Y, Shibata S, Circadian rhythm and food/nutrition. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, Springer, 2014, 237-260.

  13. Shibata S, Tahara Y, Hirao A, The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs, Advanced Drug Delivery Reviews, 2010, 62, 918-927.

  14. Shibata S, Hirao A, Tahara Y, Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm, Sleep & Biological Rhythms, 2010, 8, 18-27.

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